Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling.

@article{Chalazonitis2011BoneMP,
  title={Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling.},
  author={Alcm{\`e}ne Chalazonitis and Fabien D'autr{\'e}aux and Tuan D. Pham and John A Kessler and Michael David Gershon},
  journal={Developmental biology},
  year={2011},
  volume={350 1},
  pages={64-79}
}
The neural crest-derived cell population that colonizes the bowel (ENCDC) contains proliferating neural/glial progenitors. We tested the hypothesis that bone morphogenetic proteins (BMPs 2 and 4), which are known to promote enteric neuronal differentiation at the expense of proliferation, function similarly in gliogenesis. Enteric gliogenesis was analyzed in mice that overexpress the BMP antagonist, noggin, or BMP4 in the primordial ENS. Noggin-induced loss-of-function decreased, while BMP4… CONTINUE READING

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