Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus)

  title={Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus)},
  author={Ugo Ripamonti and Manolis Heliotis and B van den Heever and A. Hari Reddi},
  journal={Journal of periodontal research},
  volume={29 6},

Osteogenic inhibition by rat periodontal ligament cells: modulation of bone morphogenic protein-7 activity in vivo

Data show that BMP-7 promoted the proliferation of precursor cells in the periodontal ligament but did not induce osteogenic differentiation in this compartment, indicating that a powerful osteogenic stimulus like B MP-7 cannot significantly perturb the mechanisms that regulate periodont alveolar ligament width and maintainperiodontal homeostasis.

Recombinant Human Bone Morphogenetic Protein-2 Promotes Wound Healing in Rat Periodontal Fenestration Defects

A single dose of rhBMP-2 increased the rate of normal intramembranous bone formation and selectively enhanced cementum formation coronally during early wound healing, suggesting the importance of developing a suitable delivery system to maintain the concentration of B MP-2 at the site of implantation for potential therapeutic use.

Redefining the induction of periodontal tissue regeneration in primates by the osteogenic proteins of the transforming growth factor-β supergene family.

Molecular redundancy with associated different biological functionalities in primate tissues may simply represent the fine-tuning of speciation-related molecular evolution in anthropoid apes at the early Pliocene boundary, which resulted in finer tuning of the bone induction cascade.

Cementogenesis and osteogenesis in periodontal tissue regeneration by recombinant human transforming growth factor‐&bgr;3: a pilot study in Papio ursinus

Cementogenesis and osteogenesis by hTGF-β3 entail the expression and up-regulation of TGF- β3 and OC with fine tuning and modulation of BMP-2 and OP-1.

Bone morphogenetic proteins, cementogenesis, myoblastic stem cells and the induction of periodontal tissue regeneration.

The induction of bone formation: From bone morphogenetic proteins to the transforming growth factor-β3 protein - Redundancy, pleiotropy and the induction of cementogenesis

The rapid induction of bone by hT GF-β3 provides the framework for a paradigmatic shift from recombinanthBMPs to hTGF- β3 in clinical contexts, provocatively operational in periodontal tissue regeneration with substantial induction of cementogenesis in angiogenesis.

LPCGF and EDTA conditioning of the root surface promotes the adhesion, growth, migration and differentiation of periodontal ligament cells.

EDTA and LPCGF application to periodontitis-affected root surfaces forms a surface suitable for cell attachment, growth, migration and differentiation, and is promising in clinical periodontics applications.

Protein- and Cell-Based Therapies for Periodontal Regeneration

In this chapter, the current status of protein- and cell-based therapies for periodontal regeneration are reviewed, with an emphasis on products that have been tested in clinical studies.



Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

  • A. ParfittM. Drezner R. Recker
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1987
A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.

Reconstruction of the Bone‐Bone Marrow Organ by Osteogenin, a Bone Morphogenetic Protein, and Demineralized Bone Matrix in Calvarial Defects of Adult Primates

The phenotypic evidence of endochondral bone differentiation by induction in defects of membranous calvarial bone in adult primates is provided, establishing the potential therapeutic application of osteogenin and demineralized bone matrix for the architectural reconstruction of the bone-bone marrow organ in humans.

Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix.

  • T. SampathA. Reddi
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1983
Observations demonstrate that species specificity of xenogenic extracellular bone matrix is due to immunogenic or inhibitory components in the guanidine X HCl residue and solubilizedextracellular matrix components of greater than 50,000 daltons.

Regulation of cartilage and bone differentiation by bone morphogenetic proteins.

  • A. Reddi
  • Biology, Medicine
    Current opinion in cell biology
  • 1992

The transforming growth factor-beta family.

The bone morphogenetic protein family and osteogenesis

  • J. Wozney
  • Biology
    Molecular reproduction and development
  • 1992
These studies demonstrate that the BMP mRNAs are spatially and temporally expressed appropriately for the proteins involved in the induction and development of cartilage and bone in the embryonic limb bud.

Periodontal repair in dogs: healing in experimentally created chronic periodontal defects.

It is indicated that healing may vary not only as a result of controlled experimental variables, but also due to differences in biological response between dogs or to fortuitous traumatic factors.

Periodontal regeneration: potential role of bone morphogenetic proteins.

The availability of recombinant human BMPs provides several challenges and opportunities to gain insights into the mechanisms regulating the regeneration of bone and cementum for optimal outcome in the periodontal patient.