Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.

@article{Zhang2003BoneMP,
  title={Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.},
  author={Shen Zhang and Ivana Fantozzi and Donna D. Tigno and Eunhee S. Yi and Oleksandr Platoshyn and Patricia A Thistlethwaite and Jolene M. Kriett and Gordon L. Yung and Lewis J. Rubin and Jason X.-J. Yuan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 3},
  pages={
          L740-54
        }
}
  • S. ZhangI. Fantozzi J. Yuan
  • Published 1 September 2003
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Mutations of the bone morphogenetic protein (BMP) receptor type II (BMP-RII) gene have been implicated in patients with familial and sporadic PPH. The objective of this study was to elucidate the apoptotic effects of BMPs on normal human PASMCs and to examine whether BMP-induced effects are altered in… 
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BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.

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BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia

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The BMP system is strongly involved in pphPASMC mitosis through ALK-6, which possibly leads to activation of Smad and MAPK, resulting in the progression of vascular remodeling of pulmonary arteries in PPH.

Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?

  • N. Morrell
  • Biology, Medicine
    Proceedings of the American Thoracic Society
  • 2006
The combination of increased endothelial apoptosis and failure of growth suppression in pulmonary artery smooth muscle cells provides important clues to the cellular pathogenesis of PAH.

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