Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.

  title={Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.},
  author={Shen Zhang and Ivana Fantozzi and Donna D. Tigno and Eunhee S. Yi and Oleksandr Platoshyn and Patricia A Thistlethwaite and Jolene M. Kriett and Gordon L. Yung and Lewis J. Rubin and Jason X.-J. Yuan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={285 3},
  • S. ZhangI. Fantozzi J. Yuan
  • Published 1 September 2003
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Mutations of the bone morphogenetic protein (BMP) receptor type II (BMP-RII) gene have been implicated in patients with familial and sporadic PPH. The objective of this study was to elucidate the apoptotic effects of BMPs on normal human PASMCs and to examine whether BMP-induced effects are altered in… 

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