Bone morphogenetic proteins as regulators of iron metabolism.

  title={Bone morphogenetic proteins as regulators of iron metabolism.},
  author={Nermi L Parrow and Robert E. Fleming},
  journal={Annual review of nutrition},
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-β) superfamily of signaling molecules. In addition to protean roles in embryonic development, germ-line specification, and cellular differentiation, a central role in iron homeostasis has recently been demonstrated for certain BMPs. Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin. This regulation occurs via cellular SMAD… CONTINUE READING