Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension

@article{Caestecker2001BoneMP,
  title={Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension},
  author={Mark P. de Caestecker and Barbara O. Meyrick},
  journal={Respiratory Research},
  year={2001},
  volume={2},
  pages={193 - 197}
}
Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology that is associated with the inheritance and/or spontaneous development of germline mutations in the bone morphogenetic protein receptor (BMPR) type II gene. Because BMPR-II is a ubiquitously expressed receptor for a family of secreted growth factors known as the bone morphogenetic proteins (BMPs), these findings suggest that BMPs… CONTINUE READING
23 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Mutations in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred

  • JH Newman, L Wheller, +4 authors JE Loyd
  • N Engl J Med 2001:in press
  • 2001
1 Excerpt

Skeletal Growth Factors

  • M Kawabata, K Miyazono
  • 2000
3 Excerpts

Similar Papers

Loading similar papers…