Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension.

@article{Reynolds2007BoneMP,
  title={Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension.},
  author={Ann Marie Reynolds and Wei Xia and Mark D. Holmes and Sandra Hodge and Sergei M. Danilov and David T. Curiel and Nicholas W. Morrell and Paul N Reynolds},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 5},
  pages={
          L1182-92
        }
}
Idiopathic pulmonary arterial hypertension (PAH) is characterized by proliferation of pulmonary vascular endothelial and smooth muscle cells causing increased vascular resistance and right heart failure. Mutations in the bone morphogenetic protein receptor type 2 (BMPR2) are believed to cause the familial form of the disease. Reduced expression of BMPR2 is also noted in secondary PAH. Recent advances in the therapy of PAH have improved quality of life and survival, but many patients continue to… 

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  • Medicine, Biology
    European Respiratory Journal
  • 2017
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...

References

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