Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.

@article{Tsumaki2002BoneMP,
  title={Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.},
  author={Noriyuki Tsumaki and Takanobu Nakase and Takahiro Miyaji and Masaaki Kakiuchi and Tomoatsu Kimura and Takahiro Ochi and Hideki Yoshikawa},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 5},
  pages={898-906}
}
The bone morphogenetic protein (BMP) family consists of a large number of members and has diverse biological activities during development. Various tissues express pleural BMP family members, which seem to cooperatively regulate developmental events. Here, multiple BMP signals were inactivated in chondrocytes to clarify the function of BMPs during skeletogenesis. To obtain tissue-specific inactivation, Noggin gene (Nog) was overexpressed in cartilage under the control of a2(XI) collagen gene… CONTINUE READING

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