Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation.

@article{BeleckyAdams2002BoneMP,
  title={Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation.},
  author={Teri Louise Belecky-Adams and Ruben Adler and David C. Beebe},
  journal={Development},
  year={2002},
  volume={129 16},
  pages={3795-802}
}
Previous studies showed that the retina produces factors that promote the differentiation of lens fiber cells, and identified members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as potential fiber cell differentiation factors. A possible role for the bone morphogenetic proteins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses. We have now observed that phosphorylated SMAD1, an indicator of signaling through BMP receptors… CONTINUE READING

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