Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation.

  title={Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation.},
  author={Sandrine Levet and Delphine Ciais and Galina Merdzhanova and Christine Mallet and Teresa A. Zimmers and Se-Jin Lee and Fabrice P Navarro and Isabelle Texier and Jean-Jacques Feige and Sabine Bailly and Daniel Vittet},
  volume={122 4},
Lymphatic vessels are critical for the maintenance of tissue fluid homeostasis and their dysfunction contributes to several human diseases. The activin receptor-like kinase 1 (ALK1) is a transforming growth factor-β family type 1 receptor that is expressed on both blood and lymphatic endothelial cells (LECs). Its high-affinity ligand, bone morphogenetic protein 9 (BMP9), has been shown to be critical for retinal angiogenesis. The aim of this work was to investigate whether BMP9 could play a… CONTINUE READING
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