Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment.

@article{Morrissey2010BoneMP,
  title={Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment.},
  author={Colm M Morrissey and Lisha G. Brown and Tiffany E M Pitts and Robert L. Vessella and Eva Corey},
  journal={Neoplasia},
  year={2010},
  volume={12 2},
  pages={192-205}
}
Bone morphogenetic protein (BMP) signaling is important in prostate development and prostate cancer (PCa) progression. However, because of the multiple effects of different BMPs, no final conclusions have been made as to the role of BMPs in PCa. In our studies, we have focused on BMP-7 because it is involved in prostate morphogenesis, and its expression is regulated by androgens. The objective of our study was to determine BMP-7 expression in PCa metastases and investigate the effects of BMP-7… CONTINUE READING
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