Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.

@article{Notting2007BoneMP,
  title={Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.},
  author={Irene Christa Notting and Jeroen Buijs and Ratna E Mintardjo and Geertje van der Horst and Slobodan Vuki{\vc}evi{\'c} and Clemens W. G. M. Lowik and Nicoline E Schalij-Delfos and Jan Ernest Everard Keunen and Gabri van der Pluijm},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 11},
  pages={4882-9}
}
PURPOSE Bone morphogenetic protein-7 (BMP7), a member of the TGF-beta superfamily, is essential for early ocular morphogenesis, and lack of BMP7 causes epithelial development disturbances in the eye. In the present study, the association of tumorigenicity and malignant behavior of human uveal melanoma with BMP7 expression and the possibility that overexpression of BMP7 in uveal melanoma affects intraocular tumor growth in vivo were investigated. METHODS To establish the role of BMP7 in uveal… CONTINUE READING
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BMP7 inhibits tumor progression in orthotopic and bone metastatic breast cancer models

  • JT Buijs, NV Henriquez, PGM van Overveld
  • Cancer Res
  • 2007
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