Bone morphogenetic protein-7 inhibits endothelial-mesenchymal transition in pulmonary artery endothelial cell under hypoxia.

@article{Zhang2018BoneMP,
  title={Bone morphogenetic protein-7 inhibits endothelial-mesenchymal transition in pulmonary artery endothelial cell under hypoxia.},
  author={Hongyue Zhang and Ying Liu and Lixin Yan and Wei Du and Xiaodan Zhang and Min Zhang and He Chen and Yafeng Zhang and Jianqiu Zhou and Hanliang Sun and Daling Zhu},
  journal={Journal of cellular physiology},
  year={2018},
  volume={233 5},
  pages={4077-4090}
}
Pulmonary artery hypertension (PAH) is characterized by structural changes in pulmonary arteries. Increased numbers of cells expressing α-smooth muscle actin (α-SMA) is a nearly universal finding in the remodeled artery. It has been confirmed endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-SMA-expressing cells. In addition, the EndoMT is reversible. Here, we show that under hypoxia, the expression of bone morphogenetic protein 7 (BMP-7) was decreased both in vivo and… CONTINUE READING