Bone morphogenetic protein-4 regulation in fibrodysplasia ossificans progressiva.

@article{Olmsted2003BoneMP,
  title={Bone morphogenetic protein-4 regulation in fibrodysplasia ossificans progressiva.},
  author={Elizabeth Olmsted and Frederick S. Kaplan and Eileen M Shore},
  journal={Clinical orthopaedics and related research},
  year={2003},
  volume={408},
  pages={
          331-43
        }
}
Fibrodysplasia ossificans progressiva is a rare genetic disorder in which connective tissues are replaced with heterotopic bone through an endochondral process. Bone morphogenetic protein-4 messenger ribonucleic acid and protein levels are elevated in the cells of patients with fibrodysplasia ossificans progressiva, but the molecular mechanism of this steady-state elevation is unknown. Nuclear run-on assays and messenger ribonucleic acid stability assays were done to examine the molecular… CONTINUE READING

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