Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.

@article{Park2013BoneMP,
  title={Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.},
  author={Eun-Sil Park and Dori C Woods and Jonathan L Tilly},
  journal={Fertility and sterility},
  year={2013},
  volume={100 5},
  pages={
          1468-75
        }
}
OBJECTIVE To test whether bone morphogenetic protein 4 (BMP4) directly regulates differentiation of adult mouse ovary-derived oogonial stem cells (OSCs) in vitro. DESIGN Animal study. SETTING Research laboratory. ANIMAL(S) Adult C57BL/6 female mice. INTERVENTION(S) After purification from adult ovaries by fluorescence-activated cell sorting, OSCs were cultured without or with BMP4 in the absence or presence of the BMP4 antagonist, Noggin. MAIN OUTCOME MEASURE(S) Rates of in vitro… CONTINUE READING

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