Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development.

@article{Takei2009BoneMP,
  title={Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development.},
  author={Shunsuke Takei and Hinako Ichikawa and Kohei Johkura and Akimi Mogi and Heesung No and Susumu Yoshie and Daihachiro Tomotsune and Katsunori Sasaki},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 6},
  pages={H1793-803}
}
Cardiomyocytes derived from human embryonic stem (ES) cells are a potential source for cell-based therapy for heart diseases. We studied the effect of bone morphogenetic protein (BMP)-4 in the presence of fetal bovine serum (FBS) on cardiac induction from human H1 ES cells during embryoid body (EB) development. Suspension culture for 4 days with 20% FBS produced the best results for the differentiation of early mesoderm and cardiomyocytes. The addition of Noggin reduced the incidence of beating… CONTINUE READING
29 Extracted Citations
49 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 29 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…