Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

@article{Lombardo2011BoneMP,
  title={Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.},
  author={Ylenia Lombardo and Alessandro Scopelliti and Patrizia Cammareri and Matilde Todaro and Flora Iovino and Lucia Ricci-Vitiani and Gaspare Gulotta and Francesco Dieli and Ruggero de Maria and Giorgio Stassi},
  journal={Gastroenterology},
  year={2011},
  volume={140 1},
  pages={297-309}
}
BACKGROUND & AIMS The limited clinical response observed in many patients with colorectal cancer may be related to the presence of chemoresistant colorectal cancer stem cells (CRC-SCs). Bone morphogenetic protein 4 (BMP4) promotes the differentiation of normal colonic stem cells. We investigated whether BMP4 might be used to induce differentiation of CRC-SCs and for therapeutic purposes. METHODS CRC-SCs were isolated from 25 tumor samples based on expression of CD133 or using a selection… CONTINUE READING