Bone morphogenetic protein-4 enhances cardiomyocyte differentiation of cynomolgus monkey ESCs in knockout serum replacement medium.

@article{Hosseinkhani2007BoneMP,
  title={Bone morphogenetic protein-4 enhances cardiomyocyte differentiation of cynomolgus monkey ESCs in knockout serum replacement medium.},
  author={Mohsen Hosseinkhani and Hossein Hosseinkhani and Ali Khademhosseini and Fiona Bolland and Hisatoshi Kobayashi and Susanna Prat Gonzalez},
  journal={Stem cells},
  year={2007},
  volume={25 3},
  pages={571-80}
}
Despite extensive research in the differentiation of rodent ESCs into cardiomyocytes, there have been few studies of this process in primates. In this study, we examined the role of bone morphogenic protein-4 (BMP-4) to induce cardiomyocyte differentiation of cynomolgus monkey ESCs. To study the role of BMP-4, EBs were formed and cultured in Knockout Serum Replacement (KSR) medium containing BMP-4 for 8 days and subsequently seeded in gelatin-coated dishes for 20 days. It was found that ESCs… CONTINUE READING

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