Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.

@article{Kster1991BoneMP,
  title={Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.},
  author={Manfred K{\"o}ster and Sigrun Plessow and Joachim H. Clement and Andreas Lorenz and Heinz Tiedemann and Walter Knoechel},
  journal={Mechanisms of development},
  year={1991},
  volume={33 3},
  pages={
          191-9
        }
}
We have screened a Xenopus ovary cDNA library using a synthetic oligonucleotide derived from that part of the inhibin beta A sequence, which is highly conserved within the TGF-beta family. Out of several clones yielding autoradiographic signals four turned out to represent Xenopus counterparts to the human bone morphogenetic protein 4 (BMP-4). Each two of the four sequences are nearly identical and probably account for different alleles whereas the two pairs showing 5% divergence may have… CONTINUE READING

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