Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

@article{Bonner2011BoneMP,
  title={Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.},
  author={Caroline K. Bonner and Angela M. Farrelly and Caoimh{\'i}n G. Concannon and Heiko Dussmann and Mathurin Baqui{\'e} and Isabelle Virard and Hella Wobser and Donat K{\"o}gel and Claes B Wollheim and Marjan Rupnik and Maria M. Byrne and H. Koenig and Jochen H. M. Prehn},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 29},
  pages={25719-28}
}
Inactivating mutations in the transcription factor hepatocyte nuclear factor (HNF) 1A cause HNF1A-maturity-onset diabetes of the young (HNF1A-MODY), the most common monogenic form of diabetes. To examine HNF1A-MODY-induced defects in gene expression, we performed a microarray analysis of the transcriptome of rat INS-1 cells inducibly expressing the common hot spot HNF1A frameshift mutation, Pro291fsinsC-HNF1A. Real-time quantitative PCR (qPCR), Western blotting, immunohistochemistry, reporter… CONTINUE READING