Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade.

@article{Dmitriev2010BoneMP,
  title={Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade.},
  author={Anton E. Dmitriev and Suzanne Farhang and Ronald A Lehman and Geoffrey S. F. Ling and Aviva J. Symes},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2010},
  volume={10 1},
  pages={
          16-25
        }
}
BACKGROUND CONTEXT The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) and its indications for spinal fusion continue to be expanded with recent reports citing spinal trauma application. However, there are no data establishing the effects of rhBMP-2 on the injured spinal cord. PURPOSE The purpose of this study was to evaluate the extent of bone morphogenetic protein (BMP)-specific intrathecal signaling after application to the spine at various time points after a spinal cord… CONTINUE READING

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