Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures.

@article{Blackwell2009BoneMP,
  title={Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures.},
  author={Katherine A Blackwell and Peter Hortschansky and Srdan Sanovic and Shilpa Choudhary and Lawrence G. Raisz and Carol C. Pilbeam},
  journal={Prostaglandins & other lipid mediators},
  year={2009},
  volume={90 3-4},
  pages={76-80}
}
Bone morphogenetic protein 2 (BMP-2) is used clinically to stimulate bone formation and accelerate fracture repair. Adding prostaglandin (PG) E(2) or PGE(2) receptor agonists to BMP-2 has been proposed to improve BMP-2 efficacy. However, this may enhance bone resorption, since PGE(2) can increase receptor activator of NF-kappaB ligand (RANKL) expression and… CONTINUE READING