Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway

@article{Chattopadhyay2017BoneMP,
  title={Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway},
  author={Tandrika Chattopadhyay and Rajiv Ranjan Singh and Sarika Gupta and Avadhesha Surolia},
  journal={BioFactors},
  year={2017},
  volume={43},
  pages={195–209}
}
  • Tandrika Chattopadhyay, Rajiv Ranjan Singh, +1 author Avadhesha Surolia
  • Published in BioFactors 2017
  • Medicine, Biology
  • A direct link between development of insulin resistance and the presence of chronic inflammation, in case of obesity exists, with cytokines playing an important role in glucose metabolism. Members of TGF-β superfamily, including bone morphogenetic proteins (BMPs), have been shown to be involved in islet morphogenesis, establishment of β-cell mass and adipose cell fate determination. Here, we demonstrate a novel and direct role of BMP-4 and -7 in the regulation of glucose homeostasis and insulin… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    1
    Twitter Mention

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 14 CITATIONS

    Sericin enhances the insulin-PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 48 REFERENCES

    The authors showed that BMP-7 induces pancreatic exocrine-toendocrine tissue conversion in human adult tissue

    • D. Klein, S. Alvarez-Cubela, +3 authors R K.
    • Diabetes
    • 2015
    VIEW 1 EXCERPT

    BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy.

    VIEW 1 EXCERPT