Bone mineral density of the axial skeleton in acromegaly.

  title={Bone mineral density of the axial skeleton in acromegaly.},
  author={Phoebe Ho and Lorraine M. Fig and Ariel L Barkan and Brahm Shapiro},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={33 9},
Acromegaly is characterized by growth hormone (GH) hypersecretion and insulin-like growth factor-I (IGF-I) excess, both of which stimulate osteoblast proliferation. At diagnosis, GH excess has usually been present for years. Furthermore, impaired gonadotropin secretion with hypogonadism is frequent. To date, studies of changes in bone mineral density (BMD) in acromegaly have been limited and the available data inconsistent. To investigate the effects of GH excess on proximal femur and lumbar… CONTINUE READING