Bone mineral density in pseudohypoparathyroidism type 1a.

  title={Bone mineral density in pseudohypoparathyroidism type 1a.},
  author={Dominique N Long and Michael A Levine and Emily L. Germain-Lee},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={95 9},
CONTEXT The biochemical hallmark of pseudohypoparathyroidism type 1a (PHP1a) is resistance to PTH, but based on tissue-specific imprinting of GNAS, PTH resistance may be limited to the renal cortex. Some studies have shown that bone is responsive to PTH, suggesting that PHP1a patients with chronically elevated PTH levels may have low bone mineral density (BMD). SETTING This observational study was conducted at the Institute of Clinical and Translational Research, Johns Hopkins Medical… CONTINUE READING
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