Bone mineral density directly correlates with elevated serum leptin in haemodialysis patients.

@article{Ghazali2003BoneMD,
  title={Bone mineral density directly correlates with elevated serum leptin in haemodialysis patients.},
  author={Abderrahmane Ghazali and Franck Grados and Roxana Oprisiu and Delia Bunea and Philippe Morini{\`e}re and Najeh El Esper and Isabelle El Esper and Michel Brazier and Jean Claude Souberbielle and Albert Fournier and Thierry Thomas},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2003},
  volume={18 9},
  pages={
          1882-90
        }
}
BACKGROUND Experimentally, leptin has a positive effect on bone mass when infused intravenously, but a negative one after intracerebroventricular administration. Renal failure increases its serum level above the concentration beyond which its transport to the brain may be saturated. Thus, we tested, in a chronic haemodialysis population, the hypothesis of a positive relationship between serum leptin and bone mineral density (BMD) when serum levels are above this threshold. METHODS Serum… CONTINUE READING

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