Bone mineral density and effects of growth hormone treatment in prepubertal children with Prader-Willi syndrome: a randomized controlled trial.

@article{Wijngaarden2009BoneMD,
  title={Bone mineral density and effects of growth hormone treatment in prepubertal children with Prader-Willi syndrome: a randomized controlled trial.},
  author={Roderick F A de Lind van Wijngaarden and Dederieke A. M. Festen and Barto J. Otten and Edgar G A H van Mil and Joost Rotteveel and Roelof J H Odink and Mari{\"e}tte van Leeuwen and Danny A J P Haring and Gianni Bocca and E C A Mieke Houdijk and Anita C. S. Hokken-Koelega},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 10},
  pages={3763-71}
}
BACKGROUND Bone mineral density (BMD) is unknown in children with Prader-Willi syndrome (PWS), but is decreased in adults with PWS. In patients with GH deficiency, BMD increases during GH treatment. OBJECTIVES The aim of the study was to evaluate BMD in children with PWS and to study the effects of GH treatment. DESIGN We conducted a randomized… CONTINUE READING