Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis.

@article{Ronday1997BoneMD,
  title={Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis.},
  author={Herman K Ronday and Hermelijn H Smits and Paul H A Quax and Gabri van der Pluijm and Clemens W G M L{\"o}wik and Ferdinand C. Breedveld and Jan H. Verheijen},
  journal={British journal of rheumatology},
  year={1997},
  volume={36 1},
  pages={9-15}
}
The observed increase in urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) in synovial tissue of patients with rheumatoid arthritis (RA) suggests pathophysiological involvement of the plasminogen activation (PA) system in inflammatory joint disease. In the present study, we investigated the capacity of the PA system to degrade non-mineralized and mineralized bone-like matrix in vitro as a model for bone destruction. Transfected mouse LB6 cell lines, that expressed either… CONTINUE READING

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