Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

  title={Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation},
  author={Yael Alippe and Chun Wang and Biancamaria Ricci and Jianqiu Xiao and Chao Qu and Wei Zou and Deborah V Novack and Yousef Abu-Amer and Roberto Civitelli and Gabriel Mbalaviele},
  booktitle={Scientific Reports},
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific activation of the inflammasomes, we tested the hypothesis that bone matrix components function as DAMPs for the NLRP3 inflammasome and regulate osteoclast differentiation. Indeed, bone particles cause exuberant osteoclastogenesis in the… CONTINUE READING
1 Extracted Citations
55 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 55 references

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

  • C Wang
  • Cell Death & Dis. 7,
  • 2016

the case for IL-1 family cytokines as the canonical DAMPs of the immune system

  • Martin, S. J. Cell death, inflammation
  • FEBS J. 283, 2599–2615
  • 2016

Similar Papers

Loading similar papers…