Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

@inproceedings{Alippe2017BoneMC,
  title={Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation},
  author={Yael Alippe and Chun Wang and Biancamaria Ricci and Jianqiu Xiao and Chao Qu and Wei Zou and Deborah V Novack and Yousef Abu-Amer and Roberto Civitelli and Gabriel Mbalaviele},
  booktitle={Scientific Reports},
  year={2017}
}
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific activation of the inflammasomes, we tested the hypothesis that bone matrix components function as DAMPs for the NLRP3 inflammasome and regulate osteoclast differentiation. Indeed, bone particles cause exuberant osteoclastogenesis in the… CONTINUE READING
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