Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo.

@article{Mallet2002BoneMT,
  title={Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo.},
  author={Vincent Mallet and Claudia Mitchell and {\'E}va Mezey and Monique Fabre and JaniceL. Guidotti and Laurent R{\'e}nia and Laure Coulombel and Axel Kahn and H{\'e}l{\`e}ne Gilgenkrantz},
  journal={Hepatology},
  year={2002},
  volume={35 4},
  pages={
          799-804
        }
}
Cell-based therapy may some day be a therapeutic alternative to liver transplantation. Recent observations indicating that hematopoietic stem cells can differentiate into hepatocytes have opened new therapeutic prospects. However, the clinical relevance of this phenomenon is unknown. We have previously developed a strategy based on the protective effect of Bcl-2 against Fas-mediated apoptosis to selectively amplify a small number of hepatocytes in vivo. We now show that this approach can be… CONTINUE READING
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