Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.

Abstract

BACKGROUND Successful hematopoietic cell allotransplantation results in donor-specific tolerance, but this approach has been unsuccessful in the wild-type pig-to-baboon xenotransplantation model, as pig cells were lost from the circulation within 5 days. However, after cessation of immunosuppressive therapy on day 28, all baboons demonstrated non-specific… (More)

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