Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft-versus-leukaemia effect.

@article{Apperley1988BoneMT,
  title={Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft-versus-leukaemia effect.},
  author={Jane F. Apperley and Francesca Romana Mauro and J M Goldman and W. J. Gregory and C. K. Arthur and Jill M Hows and William Arcese and Giuseppe Papa and Franco Mandelli and David Wardle},
  journal={British journal of haematology},
  year={1988},
  volume={69 2},
  pages={239-45}
}
We analysed the incidence of graft failure, graft-versus-host disease (GVHD) and relapse of leukaemia in 208 patients undergoing allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia in chronic phase in eight transplant centres in Europe and the United States. 106 patients received unmanipulated donor bone marrow (Group 1) and 102 patients received marrow depleted of T-cells by incubation with the monoclonal antibodies Campath-1 or CT-2 and complement (Group 2). The… CONTINUE READING