Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens.

@article{Woods1990BoneMT,
  title={Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens.},
  author={William G A Woods and Norma K. C. Ramsay and Daniel J. Weisdorf and R J Haake and Daniel A. Vallera and Tae Hyun Kim and L L Lasky and Mark E. Nesbit and Bruce C Bostrom and Fatih M. Uckun},
  journal={Bone marrow transplantation},
  year={1990},
  volume={6 1},
  pages={9-16}
}
The efficacy of a pre-bone marrow transplantation (BMT) preparative regimen consisting of single, high dose rate total body irradiation followed by 12 courses of high dose cytosine arabinoside (Ara-C) over 6 days with allogeneic or autologous rescue was studied in 68 consecutive patients with poor risk acute lymphocytic leukemia (ALL). Toxicity associated with the above preparative regimen included conjunctivitis in the majority of patients, severe gastrointestinal symptoms in seven patients… CONTINUE READING

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