Bone marrow stromal colony formation requires stimulation by haemopoietic cells.

@article{Friedenstein1992BoneMS,
  title={Bone marrow stromal colony formation requires stimulation by haemopoietic cells.},
  author={A. J. Friedenstein and Natalia V. Latzinik and Gorskaya YuF and E. A. Luria and I L Moskvina},
  journal={Bone and mineral},
  year={1992},
  volume={18 3},
  pages={199-213}
}
In mouse bone marrow cultures plated at low cell density, stromal colonies formed from colony-forming unit fibroblastic (CFUf) failed to develop unless the cultures were supplemented with irradiated feeder cells. Colony-stimulating activity was produced by irradiated bone marrow and spleen cells and by platelets, was dose dependent, not species specific and was maximal at high serum concentration. The efficiency of CFUf colony formation was 1.7 x 10(-4) for mechanically disaggregated and 14.6 x… CONTINUE READING

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