Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells

@article{Lwin2007BoneMS,
  title={Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells},
  author={Tint Lwin and Lori A. Hazlehurst and Zaomin Li and Sophie Dessureault and Eduardo M. Sotomayor and Lynn C. Moscinski and William S Dalton and Jianguo Tao},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1521-1531}
}
Stromal cells are an essential component of the bone marrow microenvironment that regulate or supports tumor survival. In this study we therefore studied the role of stromal cells in lymphoma cell survival. We demonstrated that adhesion of the B-cell lymphoma cell lines SUDH-4 and 10 to bone marrow stroma inhibited mitoxantrone-induced apoptosis. This adhesion-dependent inhibition of mitoxantrone-induced apoptosis correlated with decreased activation of caspases-8 and 9, and cleavage of caspase… CONTINUE READING

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