Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord.

@article{Wu2003BoneMS,
  title={Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord.},
  author={Sufan Wu and Yoshihisa Suzuki and Yoko Ejiri and Toru Noda and Hongliang Bai and Masaaki Kitada and Kazuya Kataoka and Masayoshi Ohta and Hirotomi Chou and Chizuka Ide},
  journal={Journal of neuroscience research},
  year={2003},
  volume={72 3},
  pages={343-51}
}
Transplantation of bone marrow stromal cells (MSCs) has been regarded as a potential approach for promoting nerve regeneration. In the present study, we investigated the influence of MSCs on spinal cord neurosphere cells in vitro and on the regeneration of injured spinal cord in vivo by grafting. MSCs from adult rats were cocultured with fetal spinal cord-derived neurosphere cells by either cell mixing or making monolayered-feeder cultures. In the mixed cell cultures, neuroshpere cells were… CONTINUE READING
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