Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.

@article{Parekkadan2011BoneMS,
  title={Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.},
  author={Biju Parekkadan and Rabi Upadhyay and Joshua Dunham and Yoshiko Iwamoto and Emiko Mizoguchi and Atsushi Mizoguchi and Ralph Weissleder and Martin L. Yarmush},
  journal={Gastroenterology},
  year={2011},
  volume={140 3},
  pages={966-75}
}
BACKGROUND & AIMS Bone marrow stromal cells (MSCs) are being evaluated as a cellular therapeutic for immune-mediated diseases. We investigated the effects of MSCs in mice with chemically induced colitis and determined the effects of CD11b(+) cells based on the hypothesis that MSCs increase numbers of regulatory T cells. METHODS Colitis was induced in mice using trinitrobenzene sulfonic acid; symptoms were monitored as a function of MSC delivery. An immunomodulatory response was determined by… CONTINUE READING

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