Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication

@article{ParaguassBraga2003BoneMS,
  title={Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication},
  author={Fl{\'a}vio Henrique Paraguass{\'u}-Braga and Radovan Borojevi{\'c} and Luis Fernando Bouzas and Marcello Andr{\'e} Barcinski and Adriana Bonomo},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={1101-1108}
}
AbstractNormal and leukemic blood cell progenitors depend upon the bone marrow (BM) stroma with which they communicate through soluble and membrane-anchored mediators, adhesive interactions and gap junctions (GJ). Regarding hematopoiesis, it is believed that it can be influenced by connexin expression, but the exact role of GJ in cell death and proliferation is not clear. Using flow cytometry, we monitored the division rate of leukemic cell lines, communicating and not communicating with… CONTINUE READING

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