Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: role of heme oxygenase-adiponectin.

@article{Abraham2008BoneMS,
  title={Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: role of heme oxygenase-adiponectin.},
  author={Nader G Abraham and Ming Li and Luca Vanella and Stephen J Peterson and Susumu Ikehara and David E Asprinio},
  journal={Journal of autoimmunity},
  year={2008},
  volume={30 3},
  pages={128-35}
}
Increase in endothelial cell sloughing and diminished function of endothelial stem cell progenitors in diabetic subjects are well known phenomena. We hypothesized that transplantation of bone marrow stem cells (BMSCs) including mesenchymal stem cells but not limited to CD34(+) stem cells into type 2 diabetic ob mice would restore insulin sensitivity and glucose tolerance. This approach, when combined with induction of HO-1 (a cytoprotective antioxidant system) in the recipient, would further… CONTINUE READING

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