Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma.

@article{Vacca1999BoneMN,
  title={Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma.},
  author={Alessandra Vacca and Domenico Ribatti and Marco Presta and Monica Minischetti and Monica Iurlaro and Roberto Ria and Andriana Albini and Federico Bussolino and Franco Dammacco},
  journal={Blood},
  year={1999},
  volume={93 9},
  pages={3064-73}
}
To assess whether the progression of plasma cell tumors is accompanied by angiogenesis and secretion of matrix-degrading enzymes, bone marrow biopsy specimens from 20 patients with monoclonal gammopathy of undetermined significance (MGUS), 18 patients with nonactive multiple myeloma (MM), and 26 patients with active MM were evaluated for their angiogenic potential and matrix-metalloproteinase (MMP) production. A fivefold increase of the factor VIII+ microvessel area was measured by a… CONTINUE READING
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