Bone marrow mononuclear cells migrate to the demyelinated sciatic nerve and transdifferentiate into Schwann cells after nerve injury: attempt at a peripheral nervous system intrinsic repair mechanism.

@article{Usach2011BoneMM,
  title={Bone marrow mononuclear cells migrate to the demyelinated sciatic nerve and transdifferentiate into Schwann cells after nerve injury: attempt at a peripheral nervous system intrinsic repair mechanism.},
  author={Vanina Usach and Bel{\'e}n Goitia and Luc{\'i}a Lavalle and Roc{\'i}o Martinez Vivot and Patricia C. Setton-Avruj},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 8},
  pages={1203-17}
}
In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution of myelin proteins MBP and P(0) and the… CONTINUE READING