Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts.

@article{Wakkach2008BoneMM,
  title={Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts.},
  author={Abdelilah Wakkach and Anna Mansour and Romain Dacquin and Emmanuel Coste and Pierre Jurdic and G. F. Carle and Claudine Blin-Wakkach},
  journal={Blood},
  year={2008},
  volume={112 13},
  pages={5074-83}
}
Finding that activated T cells control osteoclast (OCL) differentiation has revealed the importance of the interactions between immune and bone cells. Dendritic cells (DCs) are responsible for T-cell activation and share common precursors with OCLs. Here we show that DCs participate in bone resorption more directly than simply through T-cell activation. We show that, among the splenic DC subsets, the conventional DCs have the higher osteoclastogenic potential in vitro. We demonstrate that… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Inflammatory Osteoclasts Prime TNFα-Producing CD4+ T Cells and Express CX3 CR1.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2016

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…