Bone marrow microenvironment and the identification of new targets for myeloma therapy

Abstract

The development of multiple myeloma (MM) is a complex multi-step process involving both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment. Indeed, it is now well established that MM cell-induced disruption of the BM homeostasis between the highly organized cellular and… (More)
DOI: 10.1038/leu.2008.259

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