Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression

@inproceedings{Mondello2017BoneMM,
  title={Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression},
  author={Patrizia Mondello and Salvatore Cuzzocrea and Michele Navarra and Michael Mian},
  booktitle={Oncotarget},
  year={2017}
}
Despite the advent of many therapeutic agents, such as bortezomib and lenalidomide that have significantly improved the overall survival, multiple myeloma remains an incurable disease. Failure to cure is multifactorial and can be attributed to the underlying genetic heterogeneity of the cancer and to the surrounding micro-environment. Understanding the mutual interaction between myeloma cells and micro-environment may lead to the development of novel treatment strategies able to eradicate this… CONTINUE READING