Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.

@article{Glennie2005BoneMM,
  title={Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.},
  author={S. Glennie and I. Soeiro and P. J. Dyson and E. Lam and F. Dazzi},
  journal={Blood},
  year={2005},
  volume={105 7},
  pages={
          2821-7
        }
}
It has been shown that mesenchymal stem cells (MSCs) induce T cells to become unresponsive. We characterized the phenotype of these T cells by dissecting the effect of MSCs on T-cell activation, proliferation, and effector function. For this purpose, an in vitro murine model was used in which T-cell responses were generated against the male HY minor histocompatibility antigen. In the presence of MSCs, the expression of early activation markers CD25 and CD69 was unaffected but interferon-gamma… Expand
Mesenchymal Stem Cells Inhibit Dendritic Cell Differentiation and Function by Preventing Entry Into the Cell Cycle
TLDR
It is concluded that MSCs impair monocyte differentiation and function by interfering with the cell cycle and imply that M SC-induced immunosuppression might be a side product of a more general antiproliferative effect. Expand
The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function.
TLDR
This work demonstrates that the immunosuppressive effect of MSC is exclusively a consequence of an anti-proliferative activity, which targets T cells of different subpopulations, and mainly targets T cell proliferation rather than their effector function. Expand
Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34+-Derived and Monocyte-Derived Dendritic Cells1
TLDR
Data demonstrate that MSCs, next to the antiproliferative effect on T cells, have a profound inhibitory effect on the generation and function of both CD34+-derived and monocyte-derived DCs, indicating that M SCs are able to modulate immune responses at multiple levels. Expand
Mesenchymal stem cells suppress B-cell terminal differentiation.
TLDR
Results indicate that humoral factor(s) released by MSCs exert a suppressive effect on the B-cell terminal differentiation, and may be mediated through inhibition of B-lymphocyte-induced maturation protein-1 expression. Expand
Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes
TLDR
This study demonstrates a new immunomodulation mechanism of action of hMSCs through the modulation of CD8+ cells towards a non-cytotoxic and/or suppressive phenotype, which has to be taken into account in clinical trials. Expand
Murine Mesenchymal Stem Cells Suppress T Lymphocyte Activation Through IL-2 Receptor α (CD25) Cleavage by Producing Matrix Metalloproteinases
TLDR
MSC-derived matrix metalloproteinases derived from MSCs have a significant role in the suppression of IL-2 production through induction of CD25 cleavage and have a partial role inThe suppression of T cell proliferation. Expand
Human Mesenchymal Stem Cells Promote Survival of T Cells in a Quiescent State
TLDR
Overall, MSC can inhibit proliferation of activated T cells while supporting their survival in a quiescent state, providing a model of their activity inside the HSC niche, as well as disrupting the mitochondrial membrane potential regulated by Bcl‐2. Expand
Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells.
TLDR
The concerted action of mechanisms involved in the regulation of DC migration resulted in the blockade of cell migration, indicating altered DC functionality mediated by MSCl cell-derived signals and mechanisms resulting in a suppressive microenvironment. Expand
Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
TLDR
It is demonstrated that soluble mediators from culture supernatant of MSCs could suppress the proliferation of both naïve and pre-activated T cells in which IL-10 and IDO play important roles. Expand
Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress
TLDR
It is demonstrated that IDO-mediated tryptophan starvation triggered by human MSCs inhibits T-cell activation and proliferation through induction of cellular stress and thus is a common strategy of immunoregulation conserved between mouse and humans. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
TLDR
The findings indicate that MSCs escape recognition by CTLs and alloreactive NK cells, and inhibit the formation of cytotoxic T cells by secreting a soluble factor, but that they do not interfere with C TLs and NK cell lysis. Expand
Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
TLDR
It is suggested that MSCs physically hinder T cells from the contact with APCs in a noncognate fashion and inhibit naive and memory T-cell responses to their cognate antigens. Expand
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals.
TLDR
It is shown in vitro that the murine C3H10T1/2 (C3) MSC line and primary MSCs exhibit immunosuppressive properties in mixed lymphocyte reaction and that the subcutaneous injection of B16 melanoma cells led to tumor growth in allogeneic recipients only when M SCs were coinjected. Expand
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.
TLDR
Baboon MSCs have been observed to alter lymphocyte reactivity to allogeneic target cells and tissues, which may prove useful in future applications of tissue regeneration and stem cell engineering. Expand
Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
TLDR
Human MSC fail to stimulate allogeneic PBMC or T-cell proliferation in mixed cell cultures, and actively inhibit T- cell proliferation, suggesting that allogeneIC MSC transplantation might be accomplished without the need for significant host immunosuppression. Expand
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli.
TLDR
The data demonstrate that autologous or allogeneic BMSCs strongly suppress T-lymphocyte proliferation, this phenomenon that is triggered by both cellular as well as nonspecific mitogenic stimuli has no immunologic restriction, and T-cell inhibition is not due to induction of apoptosis and is likely due to the production of soluble factors. Expand
Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens1
TLDR
It was shown that MSC could blunt the cytotoxic effects of allogeneic-induced effectors to mitogen-activated targets, and exerted veto-like activity, but caused no effect on responses to recall Ags. Expand
Selection, enrichment, and culture expansion of murine mesenchymal progenitor cells by retroviral transduction of cycling adherent bone marrow cells.
TLDR
Retroviral selection of cycling adherent cells is an effective approach for enrichment of MPCs by transfection with a retroviral vector carrying both LacZ and the selective neomycin resistance (neoR) gene. Expand
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation.
TLDR
It is shown that human MSCs express IDO protein and exhibit functional IDO activity upon stimulation with IFN-gamma, identifying IDO-mediated tryptophan catabolism as a novel T-cell inhibitory effector mechanism in human M SCs. Expand
Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells.
TLDR
MPCs that proliferate without obvious senescence under clinically applicable conditions and differentiate at the single-cell level not only into mesenchymal cells but also cells of visceral mesoderm may be an ideal source of stem cells for treatment of genetic or degenerative disorders affecting cells of mesodermal origin. Expand
...
1
2
3
4
...