Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway

@article{Augello2005BoneMM,
  title={Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway},
  author={A. Augello and Roberta Tasso and S. Negrini and Andrea Amateis and F. Indiveri and R. Cancedda and G. Pennesi},
  journal={European Journal of Immunology},
  year={2005},
  volume={35}
}
Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation. Experimental evidence shows that BMSC are able to suppress the activation of the immune response by mechanisms that are still not completely understood. Thus far, in vitro studies carried using human or mouse cells indicate that autologous or allogeneic BMSC strongly suppress proliferation of T lymphocytes, triggered by cellular… Expand
Murine Mesenchymal Stem Cells Suppress T Lymphocyte Activation Through IL-2 Receptor α (CD25) Cleavage by Producing Matrix Metalloproteinases
TLDR
MSC-derived matrix metalloproteinases derived from MSCs have a significant role in the suppression of IL-2 production through induction of CD25 cleavage and have a partial role inThe suppression of T cell proliferation. Expand
Immunosuppressive properties of cloned bone marrow mesenchymal stem cells
TLDR
These findings with cloned MSCs demonstrate that these cells exert their immunosuppressive effects through both soluble factor(s) and cell-cell contact, and that lymphocytes and M SCs are mutually inhibitory on their respective proliferation. Expand
Endometrial mesenchymal stem/stromal cell modulation of T cell proliferation.
TLDR
It is concluded that, while endometrial mesenchymal stem/stromal cells can modify immune responses, their immunomodulatory repertoire may not be sufficient to restrain some T cell-mediated inflammatory events. Expand
Immunomodulatory properties and therapeutic application of mesenchymal stem cells
TLDR
This review examines the current understanding of the immunomodulatory properties of MSCs and its therapeutic implication for immune‐mediated diseases and transplant rejection. Expand
Human mesenchymal stem cells modulate B-cell functions.
TLDR
The results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role. Expand
Immunological characteristics of mesenchymal stem cells
TLDR
Mesenchymal stem cells can regulate the immune response in vitro by inhibiting the maturation of dendritic cells, as well as by suppressing the proliferation and function of T and B lymphocytes and natural killer cells. Expand
Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders.
Bone marrow-derived mesenchymal stromal cells (MSCs) represent a population of nonhematopoietic cells, which play a crucial role in supporting hematopoiesis and can differentiate into various cellExpand
PD1-mediated mesenchymal stem cells immunemodulation: the two sides of the coin
TLDR
MSC immunosuppressant function is due to the redundant combination of secreted factors and membrane receptors engaged in cell-to-cell contact and acts on the innate response by hampering the proliferation and activation of macrophages and Natural Killer cells. Expand
Different roles of PD-L1 and FasL in immunomodulation mediated by human placenta-derived mesenchymal stem cells.
TLDR
It is demonstrated that PD-L1 and FasL molecules play significant roles in immunomodulation mediated by hPMSCs, providing a rational basis for modulation of negative costimulators on hP MSCs to increase their immunosuppressive properties in their therapeutic applications. Expand
Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis.
TLDR
The results suggest an effective new therapeutic approach to target the pathogenic mechanism of autoimmune arthritis using allogeneic MSCs, which exerted their immunomodulatory function by educating antigen-specific Tregs. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli.
TLDR
The data demonstrate that autologous or allogeneic BMSCs strongly suppress T-lymphocyte proliferation, this phenomenon that is triggered by both cellular as well as nonspecific mitogenic stimuli has no immunologic restriction, and T-cell inhibition is not due to induction of apoptosis and is likely due to the production of soluble factors. Expand
Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
TLDR
It is suggested that MSCs physically hinder T cells from the contact with APCs in a noncognate fashion and inhibit naive and memory T-cell responses to their cognate antigens. Expand
Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation
TLDR
Preclinical data suggest that unrelated, human bone marrow-derived, culture-expanded MSCs may improve the outcome of allogeneic transplantation by promoting hematopoietic engraftment and limiting GVHD and their therapeutic potential should be tested in clinic. Expand
Mesenchymal Stem Cells
TLDR
The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed. Expand
Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens1
TLDR
It was shown that MSC could blunt the cytotoxic effects of allogeneic-induced effectors to mitogen-activated targets, and exerted veto-like activity, but caused no effect on responses to recall Ags. Expand
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.
TLDR
A protocol that provides rapidly expanding MSCs from 5 strains of inbred mice with differences in their media requirements for optimal growth, rates of propagation, and presence of the surface epitopes CD34, stem cell antigen-1 (Sca-1), and vascular cell adhesion molecule 1 (VCAM-1). Expand
Neural Progenitor Cells Lack Immunogenicity and Resist Destruction as Allografts
TLDR
The results indicate that allogeneic CNS progenitor cells survive at least 4 weeks in a conventional site, during which time they neither sensitize their hosts nor express detectable levels of major histocompatibility complex (MHC) class I or II, which is in accord with flow cytometric results. Expand
Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis
TLDR
Results show that IFN‐γ activated endothelial cells can inhibit T cell activation via expression of the immunoinhibitory PD‐L1 andPD‐L2 molecules. Expand
CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome1
TLDR
The possibility that autologous regulatory T cells generated ex vivo have the potential to be used as an adoptive immunotherapy to induce allograft tolerance and to control autoimmunity is raised. Expand
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
TLDR
It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family. Expand
...
1
2
3
4
...