Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche.

@article{Kubota2008BoneML,
  title={Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche.},
  author={Yoshiaki Kubota and Keiyo Takubo and Toshio Suda},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={366 2},
  pages={335-9}
}
In response to changing signals, quiescent hematopoietic stem cells (HSCs) can be induced to an activated cycling state and provide multi-lineage hematopoietic cells to the whole body via blood vessels. However, the precise localization of quiescent HSCs in bone marrow microenvironment is not fully characterized. Here, we performed whole-mount immunostaining of bone marrow and found that BrdU label-retaining cells (LRCs) definitively reside in the sinusoidal hypoxic zone distant from the… CONTINUE READING

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