Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimeras.

@article{Robinson2008BoneML,
  title={Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimeras.},
  author={Kristine M. Robinson and Sheila Markwardt and Nick Kitzerow and Nicole Moes and Mary Estrada and Richard Edward Jones},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={204 1-2},
  pages={110-7}
}
Xenotransplantation of rat bone marrow cells (BMC) into immunodeficient (SCID) mice generates chimeric mice susceptible to paralytic autoimmune CNS inflammation. Herein, we identified a disease relevant subset of transplantable BMC lacking expression of CD11b/c and CD49d. Moreover, disease susceptibility was enhanced in the presence of non-myelin specific T-cells. Only the CD11b/c negative population of BM retained the capability to populate the blood, spleen and spinal cord of recipients and… CONTINUE READING