Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.

@article{Mazo2005BoneMI,
  title={Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.},
  author={Irina B. Mazo and Marek J Honczarenko and Harry K. M. Leung and Wolfgang Weninger and Roberto Bonasio and Wolfgang J Weninger and Katharina Engelke and Lijun Xia and Rodger P McEver and Pandelakis A Koni and Leslie E Silberstein and Ulrich H von Andrian},
  journal={Immunity},
  year={2005},
  volume={22 2},
  pages={
          259-70
        }
}
Normal bone marrow (BM) contains T cells whose function and origin are poorly understood. We observed that CD8+ T cells in BM consist chiefly of CCR7+ L-selectin+ central memory cells (TCMs). Adoptively transferred TCMs accumulated more efficiently in the BM than naive and effector T cells. Intravital microscopy (IVM) showed that TCMs roll efficiently in BM microvessels via L-, P-, and E-selectin, whereas firm arrest required the VCAM-1/alpha4beta1 pathway. alpha4beta1 integrin activation did… CONTINUE READING
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