Bone marrow irradiation chimeras in the BB rat: evidence suggesting two defects leading to diabetes and lymphopoenia

@article{Scott1987BoneMI,
  title={Bone marrow irradiation chimeras in the BB rat: evidence suggesting two defects leading to diabetes and lymphopoenia},
  author={Jacob Scott and Victor H Engelhard and David C. Benjamin},
  journal={Diabetologia},
  year={1987},
  volume={30},
  pages={774-781}
}
A series of bone marrow irradiation chimeras were constructed in an attempt to determine the site of the defect(s) leading to diabetes and/or lymphopoenia in the BB rat. In BB rats that were lethally irradiated and reconstituted with T-cell-depleted Wistar-Furth (WF) rat bone marrow, the incidence of diabetes was reduced, and in animals treated with WF bone… CONTINUE READING