Bone marrow involvement by lobular carcinoma of the breast cannot be identified reliably by routine histological examination alone.

@article{Bitter1994BoneMI,
  title={Bone marrow involvement by lobular carcinoma of the breast cannot be identified reliably by routine histological examination alone.},
  author={Mitchell A. Bitter and D A Fiorito and M E Corkill and William E Huffer and Salomon Marcello Stemmer and Elizabeth J Shpall and Paul G. Archer and Wilbur A. Franklin},
  journal={Human pathology},
  year={1994},
  volume={25 8},
  pages={781-8}
}
The aims of this study were twofold: (1) to evaluate the ability of pathologists to recognize infiltration of bone marrow core biopsy specimens by breast carcinoma, particularly lobular carcinoma, using routine hematoxylin-eosin (HE) sections; and (2) if indicated, to determine the reasons for difficulties in diagnosis. Thirty-six bone cores obtained before bone marrow harvest were involved by breast carcinoma and were confirmed by pancytokeratin immunostains. Thirty of the 36 were ductal… CONTINUE READING

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